BACKGROUND: Prenatal exposure to environmental contaminants is a significant health concern because it has the potential to interfere with host metabolism, leading to adverse health effects in early childhood and…
Impact of discharge criteria on the length of stay in preterm infants: A retrospective study in Japan and Finland
CONCLUSIONS: The length of stay of preterm infants in Japan could be notably reduced by supporting the parents’ earlier readiness for discharge and allowing tube feeding at home.
Positive and negative durotaxis – mechanisms and emerging concepts
Cell migration is controlled by the coordinated action of cell adhesion, cytoskeletal dynamics, contractility and cell extrinsic cues. Integrins are the main adhesion receptors to ligands of the extracellular matrix…
Novel tools to study cell-ECM interactions, cell adhesion dynamics and migration
Integrin-mediated cell adhesion is essential for cell migration, mechanotransduction and tissue integrity. In vivo, these processes are regulated by complex physicochemical signals from the extracellular matrix (ECM). These nuanced cues,…
RUNX transcription factors are essential in maintaining epididymal epithelial differentiation
Apart from the androgen receptor, transcription factors (TFs) that are required for the development and formation of the different segments of the epididymis have remained unknown. We identified TF families…
HERC5 downregulation in non-small cell lung cancer is associated with altered energy metabolism and metastasis
CONCLUSIONS: Taken together, these results indicate that low HERC5 expression increases the metastatic potential of NSCLC in vitro and in vivo. Furthermore, HERC5-induced proteomic changes influence mitochondrial pathways, ultimately leading…
Identification of stemness-related glycosylation changes in head and neck squamous cell carcinoma
CONCLUSIONS: A mannose- and galactose-rich glycosylation niche associated with stemness-related proteins was identified.
Deep Learning Enables Automatic Detection of Joint Damage Progression in Rheumatoid Arthritis-Model Development and External Validation
CONCLUSION: AuRA had the best external validation performance and demonstrated potential for detecting longitudinal changes in joint damage. Available in https://hub.docker.com/r/elolab/aura, our algorithm can easily be applied for automatic detection…
Single-cell characterisation of tissue homing CD4 + and CD8 + T cell clones in immune-mediated refractory arthritis
CONCLUSIONS: Our findings suggest that the local environment in the synovium drives the proliferation of activated cytotoxic T cells, and both CD4 + and CD8 + T cells may contribute…
TRAF6 enhances PD-L1 expression through YAP1-TFCP2 signaling in melanoma
Immunotherapy represented by programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) monoclonal antibodies has led tumor treatment into a new era. However, the low overall response rate and…